ACE2 Monoclonal Antibody
Catalogue Numbers: MB67195-50, MB67195-100
Sizes: 50µl, 100µl
Product: Mouse IgM kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Swiss-Prot: Q9BYF1
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: ACE2 is a carboxypeptidase that catalyses the conversion of angiotensin I to angiotensin 1-9, or of angiotensin II to the vasodilator angiotensin 1-7. ACE2 is a critical component in the renin-angiotensin system (RAS). ACE2 is predominantly expressed in vascular endothelial cells of the heart and kidney and Leydig and Sertoli cells of the testis. The unique expression pattern of ACE2 determines its essential role in the regulation of cardiovascular and kidney functions, as well as fertility. ACE2 protein is localized mainly in the extracellular space with its carboxy-terminal end attached to the membrane via its transmembrane domain. Active ACE2 enzyme is secreted by cleavage at the amino terminus. Research studies have shown that ACE2 expression is elevated in human failing heart. ACE2 has also been identified as the receptor for SARS and SARS-CoV-2 coronaviruses.
Purification and Purity: This antibody is purified through a protein G column.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of ACE2 protein.
Extra Notes: Western blot analysis of ACE2 expression in 293 (A), K562 (B), MCF7 (C), SKBR3 (D), T47D (E), MDAMB453 (F), mouse testis (G) whole cell lysates.
Bioworld Molecular Weight: ~ 100-120 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15
Immunogen: Recombinant fusion protein of human ACE2. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified