ACE2 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4612-20, A4612-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.
Synonyms: ACEH; ACE2
GeneID: 59272
Swiss-Prot: Q9BYF1
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 92kDa
Observed Molecular Weight: 100kDa/120kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 18-740 of human ACE2 (NP_068576.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:100 - 1:500 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Cell Biology Developmental Biology, Ubiquitin, Cardiovascular, Blood, Heart, Contractility
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Hep G2, Mouse brain, Mouse heart, Rat brain, Rat kidney
Cellular Location: Cell Membrane, Cytoplasm, Secreted, Single-pass Type I Membrane Protein
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.