Acetyl NF kB P65（K314 K315)Mouse Monoclonal Antibody (2A11)
Sizes: 50µl, 100µl
Catalogue Number: RA10212-50, RA10212-100
Citations, Manuals and MSDS Available upon request.
Condition: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Store at: -20°C. Do not aliquot the antibody.
Recommended Dilutions: IHC: 1:100-200
Optimal dilutions should be determined by the end user.
Specificity: The antibody can detects endogenous Acetyl NF kB P65（K314/K315) proteins.
Alternative Names: NF kappa B p65, NFKB3, p65, p65 NF kB, RELA, TF65, Transcription Factor p65
Background: NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.
Applications: IHC
Species Cross-Reactivity: H, M, R
Molecular Weight: ~65KD
Isotype: IgG1
GeneID: 5970
Protein Molecular Weight (KDa): 65
SWISS: Q04206
Source: Mouse
Antigen: Synthetic Peptide
Category: Monoclonal
Research Use Only