Alpha-2-Macroglobulin (A2M) Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9752-20, A9752-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Synonyms: A2MD; CPAMD5; FWP007; S863-7; Alpha-2-Macroglobulin (A2M)
GeneID: 2
Swiss-Prot: P01023
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 163kDa
Observed Molecular Weight: 185kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human Alpha-2-Macroglobulin (A2M) (P01023).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Cell Biology Developmental Biology, Ubiquitin, Cardiovascular, Blood, Serum Proteins
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Hep G2
Cellular Location: Secreted
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.