2'-O-methyladenosine / Am Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A2388-20, A2388-100
Citations, Manuals and SDS Available upon request.
Background: Discovered in the 1970s, m6A is the most prevalent internal modification in polyadenylated mRNAs and long non-coding RNAs (lncRNAs) in higher eukaryotes. m6A is widely conserved among eukaryotic species that range from yeast, plants, flies to mammals, as well as among viral RNAs with a nuclear phase. The m6A-based modification is associated with a well-defined RNA motif, RRACH (R: A/G, H: A/C/U). As a representative of the epitranscriptome, m6A mRNA modifications participate in many vital activities in the cell, including stem cell self-renewal and differentiation, mRNA transcription, alternative splicing, nuclear export, translation, degradation, and microRNA processing. These processes determine the expression or inactivation of specific genes, which is vital for growth and development.(PMID: 30416848; PMID: 24662220; PMID: 30429466)
Synonyms: Am; 2'-O-methyladenosine; 2'-O-methyladenosine / Am
Tested Applications: ELISA, DB
Reactivity: Species independent
Immunogen: Chemical compounds corresponding to 2'-O-methyladenosine / Am.
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: DB: 1:500 - 1:2000
Modifications: 2'-O-methyladenosine / Am
Keywords: Am, 2'-O-methyladenosine, 2'-O-methyladenosine / Am
Symbol: 2mA
Category: Other Modified Antibodies
Research Use Only