ASXL1 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9890-20, A9890-100
Citations, Manuals and SDS Available upon request.
Background: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.
Synonyms: MDS; BOPS; ASXL1
GeneID: 171023
Swiss-Prot: Q8IXJ9
Reactivity: Human, Mouse
Calculated Molecular Weight: 165kDa
Observed Molecular Weight: 165kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 70-250 of human ASXL1 (NP_056153.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Epigenetics Nuclear Signaling, Nuclear Receptor Signaling, Nuclear hormone receptors, Chromatin Remodeling
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse liver
Cellular Location: Nucleus
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.