CAPN10 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9865-20, A9865-100
Citations, Manuals and SDS Available upon request.
Background: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.
Synonyms: CANP10; NIDDM1; CAPN10
GeneID: 11132
Swiss-Prot: Q9HC96
Reactivity: Human
Calculated Molecular Weight: 75kDa
Observed Molecular Weight: 68kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CAPN10 (NP_075571.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:1000 - 1:4000
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Ubiquitin, Endocrine Metabolism, Endocrine and metabolic diseases, Neuroscience, Calcium Signaling
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, A375, HepG2, HT-29
Cellular Location: Cytoplasm, Cytosol, Mitochondrion, Plasma Membrane
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.