GLDC Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9933-20, A9933-100
Citations, Manuals and SDS Available upon request.
Background: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
Synonyms: GCE; GCSP; HYGN1; GLDC
GeneID: 2731
Swiss-Prot: P23378
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 113kDa
Observed Molecular Weight: 113kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 36-290 of human GLDC (NP_000161.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC, IP
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IF/ICC: 1:50 - 1:100 | IP: 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Mitochondrial metabolism, Mitochondrial markers, Amino acid metabolism
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HepG2, DU145
Cellular Location: Mitochondrion
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.