NODAL Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9902-20, A9902-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis.
Synonyms: HTX5; NODAL
GeneID: 4838
Swiss-Prot: Q96S42
Reactivity: Human, Rat
Calculated Molecular Weight: 40kDa
Observed Molecular Weight: 44kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 198-347 of human NODAL (NP_060525.3).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Cell Biology Developmental Biology, Growth factors, TGF-b-Smad Signaling Pathway, ESC Pluripotency and Differentiation, Immunology Inflammation, Cytokines, Stem Cells, Embryonic Stem Cells
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: SH-SY5Y, HepG2, 293T, Rat liver
Cellular Location: Secreted
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.