NSD1 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9981-20, A9981-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms: STO; KMT3B; SOTOS; ARA267; SOTOS1; NSD1
GeneID: 64324
Swiss-Prot: Q96L73
Reactivity: Human, Mouse
Calculated Molecular Weight: 297kDa
Observed Molecular Weight: 267kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-260 of human NSD1 (NP_071900.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, Nuclear Receptor Signaling
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: MCF7
Cellular Location: Chromosome, Nucleus
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.