SAV1 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9980-20, A9980-100
Citations, Manuals and SDS Available upon request.
Background: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
Synonyms: SAV; WW45; WWP4; SAV1
GeneID: 60485
Swiss-Prot: Q9H4B6
Reactivity: Human, Mouse
Calculated Molecular Weight: 45kDa
Observed Molecular Weight: 45kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 199-383 of human SAV1 (NP_068590.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:1000 - 1:4000
Research Areas: Signal Transduction, Kinase, Cell Biology Developmental Biology
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, SKOV3, SW480
Cellular Location: Cytoplasm, Nucleus
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.