SOCS6 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9957-20, A9957-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
Synonyms: CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060; SOCS6
GeneID: 9306
Swiss-Prot: O14544
Reactivity: Human, Mouse
Calculated Molecular Weight: 60kDa
Observed Molecular Weight: 70kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SOCS6 (NP_004223.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, Signal Transduction, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: A-549, Mouse heart, Mouse kidney
Cellular Location: Cytoplasm, Cytosol, immunological Synapse
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.