TAB2 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9867-20, A9867-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.
Synonyms: CHTD2; TAB-2; MAP3K7IP2; TAB2
GeneID: 23118
Swiss-Prot: Q9NYJ8
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 76kDa
Observed Molecular Weight: 80kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 510-620 of human TAB2 (NP_055908.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Signal Transduction, Kinase, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Inhibition of Apoptosis, Wnt ��-Catenin Signaling Pathway, Immunology Inflammation, NF-kB Signaling Pathway, Toll-like Receptor Signaling Pathway, Cell Intrinsic Innate Immunity Signaling Pathway, TLR Signaling
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse brain, Mouse heart, Rat skeletal muscle, Rat kidney, Rat heart
Cellular Location: Cytoplasm, Membrane, Peripheral Membrane Protein, Cytosol
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.