CD252 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB66937-50, MB66937-100
Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.
Swiss-Prot: P23510
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/500 - 1/2000)
Background: OX40 is a member of the tumor necrosis factor receptor superfamily that regulates T cell activity and immune responses. The OX40 protein contains four cysteine rich domains, a transmembrane domain, and a cytoplasmic tail containing a QEE motif. OX40 is primarily expressed on activated CD4+ and CD8+ T-cells, while the OX40 ligand is predominantly expressed on activated antigen presenting cells. The engagement of OX40 with OX40L leads to the recruitment of TNF receptor-associated factors (TRAFs) and results in the formation of a TCR-independent signaling complex. One component of this complex, PKC胃, activates the NF-魏B pathway. OX40 signaling through Akt can also enhance TCR signaling directly. Research studies indicate that the OX40L-OX40 pathway is associated with inflammation and autoimmune diseases. Additional research studies show that OX40 agonists augment anti-tumor immunity in several cancer types.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of CD252 protein.
Bioworld Molecular Weight: ~ 60 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of CD252 expression in HL60 (A) whole cell lysates., ???, ???, ???
TXGP1; Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD252
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD252. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified