HMGA2 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB67017-50, MB67017-100
Product: Mouse IgG2b. Supplied in crude ascites with 0.01% sodium azide.
Swiss-Prot: P52926
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/500 - 1/4000)
Background: HMGA2 belongs to the family of high mobility group with AT-hook DNA binding domain. HMGA proteins are considered architectural transcription factors; they do not have direct transcriptional activation capacity, but instead regulate gene expression by changing DNA conformation through binding to AT-rich regions in the DNA and/or direct interaction with other transcription factors . HMGA2 is abundantly and ubiquitously expressed and plays a crucial role during embryonic development . HMGA2 promotes stem cell self-renewal and research studies have shown that decreased HMGA2 expression is associated with stem cell aging . Investigators have shown that expression levels of HMGA2 are very low in normal adult tissues, while either overexpression or rearrangement is associated with many types of cancer .
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of HMGA2 protein.
Bioworld Molecular Weight: ~ 18 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of HMGA2 expression in HepG2 (A) whole cell lysates., ???, ???, ???
HMGIC; High mobility group protein HMGI-C; High mobility group AT-hook protein 2
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HMGA2. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified