lgA Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB66771-50, MB66771-100
Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.
Swiss-Prot: P01876
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. The IgA heavy chain is an a-chain, and the light chains are either k- or l- chains. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of lgA protein.
Bioworld Molecular Weight: ~ 55 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of lgA expression in CEM (A) whole cell lysates., ???, ???, ???
Ig alpha-1 chain C region
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human lgA. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified