Recombinant Human Serpin E1 Protein
Size: 10UG
Catalogue Numbers: RP00532-10
Citations, Manuals and SDS Available upon request.
Description: Recombinant Human Serpin E1 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Val24-Pro402) of human Serpin E1 (Accession #P05121) fused with a 6×His tag at the C-terminus.
Background: Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. They are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpin E1 is a secreted protein which belongs to the Serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SERPINE1 are characterized by abnormal bleeding due to Serpin E1 defect in the plasma. High concentrations of Serpin E1 have been associated with thrombophilia which is an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis.
Synonyms: PAI, PAI-1, PAI1, PLANH1, SERPINE1
Swiss-Prot: P05121
GeneID: 5054
Species: Human
Purity: > 95% by SDS-PAGE.
Research Areas: Other Recombinant Protein
Expression System: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0. Contact us for customized product form or formulation. Endotoxin: < 1 EU/μg of the protein by LAL method.
Symbol: Serpin E1
Storage: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Keywords: Recombinant Human Serpin E1 Protein, Serpin E1, Plasminogen Activator Inhibitor 1, PAI, PAI-1, Endothelial Plasminogen Activator Inhibitor, SerpinE1, SERPINE1, PAI1, PLANH1
Research Use Only