Recombinant Mouse Fc-gamma RI/CD64 Protein
Size: 10UG
Catalogue Numbers: RP00710-10
Citations, Manuals and SDS Available upon request.
Description: Recombinant Mouse Fc γ RI/FCGR1A/CD64 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Glu25-Pro297) of mouse Fc γ RI/FCGR1A/CD64 (Accession #P26151) fused with a 6×His tag at the C-terminus.
Background: CD64, also known as Fc-gamma receptor 1 (Fc γ RI), is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity. After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation. CD64 is composed of a signal peptide, three extracellular immunoglobulin domains of the C2-typeused to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 mediates endocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxide production. It is normally expressed on the surfaces of monocytes and macrophages.
Synonyms: High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, FcRI, CD64, Fcgr1
Swiss-Prot: P26151
GeneID: 14129
Species: Mouse
Purity: > 95% by SDS-PAGE.
Research Areas: Fc & Fc Receptor
Expression System: HEK293 cells
Tag: C-His
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. Contact us for customized product form or formulation.
Endotoxin: < 1 EU/μg of the protein by LAL method.
Symbol: Fc-gamma RI/CD64
Storage: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Keywords: Recombinant Mouse Fc γ RI/FCGR1A/CD64 Protein, FCGR1A, High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, FcRI, CD64
Research Use Only