Perfused Organ Panel is a unique microphysiological system that enables continuous, parallel perfusion of 12 statistically independent organ cultures with just one tube. Media and assays are added and removed as in a standard multi-well plate. Scaffolds can be removed for cell isolation and imaging.
Catalogue Number: PS-A012-0016
Starter system includes:
- A dual syringe pump
- Sixteen 12-well PerfusionPal plates
- Sixteen syringes and tubing
- 240 SeedEZ scaffolds
- Three bottles of 100 mL blood substitute
- Three hours of plating instructions
- Two hours of application consultation
With the exception of syringe pump, all components are sterile.
The Blood Substitute provides superior delivery of respiratory gases to the basal side of cultures. It is immiscible with and insoluble in media, reagents, and drugs. The Blood Substitute is twice as dense as water and cannot grow any microorganisms enabling sterile, long-term perfusion of cultures.
Benefits include:
- Parallel perfusion of 24 cultures (12 cultures in each of two plates, perfused simultaenously)
- Superior tissue oxygenation and pH maintenance
- 2-10 times higher CYP450 activity compared to 2D cultures
- 4 times higher cellular respiration compared to 2D cultures
- High mitochondrial utilization
- Concentrated secretome for testing biologics (MAbs and ADCs)
- Concentrated metabolome for testing slow-to-metabolize drugs
- Extended mechanistic studies
- Repeat-dosing
Features:
- Standardized, 12-well integral insert system
- Media exchanges using a micropipette
- Ideal for biochemical assaying & assay multiplexing
- Removable and portable SeedEZ scaffolds
*Ships within 1 week.*