14-3-3 epsilon Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4933-20, A4933-100
Citations, Manuals and SDS Available upon request.
Background: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
Synonyms: MDS; HEL2; MDCR; KCIP-1; 14-3-3E; 14-3-3 epsilon
GeneID: 7531
Swiss-Prot: P62258
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 29kDa
Observed Molecular Weight: 28kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human 14-3-3 epsilon (P62258).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Epigenetics Nuclear Signaling, RNA Binding, Signal Transduction, PI3K-Akt Signaling Pathway, MAPK-Erk Signaling Pathway, MAPK-JNK Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Cell Cycle, Cell Cycle Control-G2 M DNA Damage Checkpoint, Neuroscience, Cell Type Marker, Dopamine Signaling in Parkinson's Disease, Neurodegenerative Diseases Markers, Stem Cells, Neuron marker, Synapse marker
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, Mouse brain, Mouse kidney, Rat lung, Rat brain
Cellular Location: Cytoplasm, Melanosome
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.