53BP1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A3859-20, A3859-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: p202; 53BP1; TDRD30; p53BP1
GeneID: 7158
Swiss Prot: Q12888
Tested Applications: ELISA, IHC-P, IF/ICC
Reactivity: Human, Mouse
Calculated Molecular Weight: 214kDa
Observed Molecular Weight: 450kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human 53BP1 (Q12888).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, DNA Damage Repair, Protein phosphorylation, Cancer, Tumor suppressors, p53 pathway, ATM Signaling Pathway
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Nuclear Body, Nucleoplasm, Nucleus
Keywords: TP53BP1, 53BP1, TDRD30, TP53, p202, p53BP1, tumor protein p53 binding protein 1, tumor suppressor p53-binding protein 1|p53-binding protein 1|tumor protein 53-binding protein, 1, Q12888
Symbol: TP53BP1
Category: Monoclonal Antibodies
Research Use Only