
Coenzyme NAD Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A21047-20, A21047-100
Citations, Manuals and SDS Available upon request.
Background: The coenzyme NAD is involved in oxidation–reduction reactions critical for glycolysis, fatty acid oxidation, the TCA cycle, and complex I of the mitochondrial respiratory chain and also is a key regulator of autophagy. At least two different mechanisms are involved. First, the NAD+-dependent deacetylase SIRT1 activates autophagy by directly deacetylating ATG proteins. Under starvation conditions, the increased NAD+/NADH ratio activates SIRT1, which results in stimulation of mitophagy. Second, the hydrogen of NADH can be transferred to NADP+ to form NADPH via the energy-linked transhydrogenase. In the fed state, when the NAD+/NADH ratio falls, NADPH inhibits autophagy by scavenging of ROS via the glutathione peroxidase-glutathione reductase system and by preventing the production of ROS at complex 1 of the respiratory chain.
GeneID: CAS:53-84-9
Tested Applications: ELISA, DB
Reactivity: Species independent
Observed Molecular Weight: Refer to figures
Immunogen: NAD
Immunogen Species: Species independent
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: DB: 1:500 - 1:1000
Research Areas: Signal Transduction, Metabolism Energy, Metabolism; Pathways and Processes, Metabolic signaling pathways, Energy transfer pathways; Energy Metabolism; Metabolism Pathways and Processes, Cofactors, Vitamins / minerals Co-factors
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Coenzyme NAD
Symbol: Coenzyme NAD
Category: Other Modified Antibodies
Research Use Only